Ethnic differences in beta cell function and pancreatic fat in Black African and White European men across a spectrum of glucose tolerance
Authors' conclusion
Ethnic differences were apparent as beta cell function was inversely associated with IPL in the WE, but not BA, men. However, in both ethnic groups, this relationship appears secondary to other factors, such as adiposity, in the pathogenesis of type 2 diabetes.
Study context
- Population
- Black African and White European men across a spectrum of glucose tolerance (normal, impaired glucose tolerance, T2D)
- Participants
- 53 vs 51
- Exposure
- Black African vs White European men
- Black African (BA)n = 53
- White European (WE)n = 51reference
- Outcome
- Association between intrapancreatic lipid (IPL, Dixon MRI) and beta cell function, and whether it differs by ethnicity
Main finding
As reported in the abstract
Association of IPL with beta cell function
- Intrapancreatic lipid (IPL) inversely associated with beta cell function in WE but not BA men; not significant after adjustment for confounders
Observational data: associations, not effects.
Further findings
IPL
P = 0.038
- Total insulin secretion response, men with T2D · lower in BA; mixed-meal
- P = 0.001
- Total insulin secretion response, men with T2D · lower in BA; hyperglycaemic clamp
- P = 0.002
- IPL: lower in BA; after adjustment for waist circumference p=0.278
Disposition index within glucose tolerance groups
- No ethnic differences in disposition index within glucose tolerance groups
Original publication
Ethnic differences in beta cell function and pancreatic fat in Black African and White European men across a spectrum of glucose tolerance. Diabetologia. Published 6 August 2025. doi:10.
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