Racial/Ethnic Differences in Associations Between Traumatic Childhood Experiences and Both Metabolic Syndrome Prevalence and Type 2 Diabetes Risk Among a Cohort of U.S. Women
Main finding · Incident T2DResult — go to the resultHazard ratio 1.13 95% CI 1.04–1.22Authors' conclusion
TCE and type 2 diabetes associations varied by race/ethnicity and were partially explained by MetS.
Study context
- Population
- Non-Hispanic White (NHW) (88%), Black/African American (BAA) (7%) and Hispanic/Latina (4%) Sister Study participants aged 35–74 years, enrolled 2003–2009
- Participants
- 42,173 participants
- Exposure
- Any traumatic childhood experiences (TCEs) vs none
- Outcome
- Incident T2D (self-reported new diagnosis)
- Follow-up
- Mean ± SD 11.1 ± 2.7 years
Methodological detailsrace/ethnicity as effect modifier, mediation analysis
- Race/ethnicity as effect modifier
- Mediation analysis
Main finding
Incident T2D
Hazard ratio
1.13
95% CI 1.04–1.22
Any TCEsvs No TCEs
HR 1.13 (95% CI 1.04–1.22)
As reported in the abstract
- By race/ethnicity: associations strongest among Latina participants, HR
- 1.64 (95% CI 1.21-2.22)
- By race/ethnicity: HR for BAA and NHW
- 1.09
Observational data: associations, not effects.
Further findings
Mediation of overall TCE–T2D association by metabolic syndrome (MetS)
- MetS mediated the overall association; indirect effect, HR
- 1.01 (95% CI 1.00-1.01); P = 0.02
- MetS was not a modifier
Original publication
Racial/Ethnic Differences in Associations Between Traumatic Childhood Experiences and Both Metabolic Syndrome Prevalence and Type 2 Diabetes Risk Among a Cohort of U.S. Women. Diabetes Care. Published 16 December 2022. doi:10.
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