Heart rate fragmentation is impaired in type 2 diabetes mellitus patients
Authors' conclusion
T2DM have increased fragmentation patterns, and words grouped by inflection type are more closely related to HRV. The HRF approach might be useful to assess heart rate dynamic abnormalities in males with type 2 diabetes.
Study context
- Population
- Men aged 47–57 years from a database; R-R intervals by ECG, supine, 10 to 15 min
- Participants
- 164 men
- Comparison
- Men with T2D vs apparently healthy men
- T2DMn = 82
- Healthyn = 82reference
- Outcome
- Heart rate fragmentation (PIP, W0–W3, WH, WS, WM) and its relationship with HRV indices
Main finding
As reported in the abstract
Heart rate fragmentation indices
- T2DM had higher percentage of inflection points (PIP), WS, WM and W3, and lower WH and W1 vs healthy
- T2DM vs Healthy: P < 0.05
Observational data: associations, not effects.
Further findings
Correlation of heart rate fragmentation (HRF) with heart rate variability (HRV) indices
- Positive moderate correlation of WH with RMSSD and high frequency (HF) indices
- Negative moderate correlation of WS and WM with RMSSD and HF indices
Original publication
Heart rate fragmentation is impaired in type 2 diabetes mellitus patients. Diabetes Res Clin Pract. Published 16 December 2022. doi:10.
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