Multiblock proteomic profiling identifies novel biomarkers linking prediabetes with preclinical atherosclerosis in apparently healthy adults
Authors' conclusion
An integrative block-sPLS-DA approach separated individuals with prediabetes from those without and revealed a proteomic signature independent of clinical covariates. Within this signature, the expression of LMOD1, EDA2R, and C16orf89 showed robust associations with atherosclerosis-related vascular traits.
Study context
- Population
- Apparently healthy adults from the Białystok PLUS cohort, Poland (mean age 49 ± 10 years; 47% males); known diabetes, major cardiovascular, inflammatory or malignant diseases, steroidal or lipid-lowering therapy excluded; preclinical atherosclerosis by carotid US
- Participants
- 389 adults
- Exposure
- Prediabetes vs no prediabetes
- Outcome
- Proteins associated with increased IMT (multivariable linear regression)
Methodological detailspopulation-based, proteomic profiling (Olink Reveal, 1050 proteins), block-sPLS-DA
- Population-based
- Proteomic profiling (Olink Reveal, 1050 proteins)
- block-sPLS-DA
Main finding
As reported in the abstract
Ectodysplasin A2 receptor (EDA2R) expression associated with increased IMT
B = 0.05
P = 0.001
C16orf89 expression associated with increased IMT
B = 0.05
P = 0.001
LMOD1 expression associated with increased IMT
B = 0.039
P = 0.016
Observational data: associations, not effects.
Further findings
Protein–clinical correlations
- Module including EDA2R and LMOD1 correlates positively with age and vascular parameters, and inversely with GFR and HDL-C
Functional enrichment
- Significant overrepresentation of proteins associated with synapse maturation
Original publication
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