Preclinical atherosclerosis and prediabetes: a cross-sectional metabolic assessment in apparently healthy population
Authors' conclusion
Prediabetes is associated with more pronounced metabolic alterations than preclinical atherosclerosis. TMAO and glutaminase activity may represent key metabolic links between these conditions. These findings highlight the potential of metabolomics in identifying early biomarkers and mechanisms relevant to the prevention of cardiometabolic diseases.
Study context
- Population
- Apparently healthy adults with low to moderate cardiovascular risk from the Białystok PLUS cohort; mean age 39.7 ± 9.6 yearsBiałystok PLUS cohort
- Participants
- 447 adults
- Exposure
- Prediabetes and preclinical atherosclerosis: shared and distinct metabolic signatures
- Outcome
- Shared and distinct metabolic signatures associated with prediabetes and preclinical atherosclerosis (434 metabolites and 218 metabolite sums or ratios)
Methodological detailstargeted metabolomics (HPLC-MS/MS), Prediabetes diagnosed by HbA1c and OGTT criteria; preclinical atherosclerosis assessed by carotid US, Analyses: ANOVA, linear regression, correlation analysis, metabolite set enrichment analysis
- Targeted metabolomics (HPLC-MS/MS)
- Prediabetes diagnosed by HbA1c and OGTT criteria; preclinical atherosclerosis assessed by carotid US
- Analyses: ANOVA, linear regression, correlation analysis, metabolite set enrichment analysis
Main finding
As reported in the abstract
- Prediabetes significantly associated with preclinical atherosclerosis
- p = 0.006
Observational data: associations, not effects.
Original publication
Preclinical atherosclerosis and prediabetes: a cross-sectional metabolic assessment in apparently healthy population. Cardiovasc Diabetol. Published 10 July 2025. doi:10.
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