Sex differences in the association between insulin resistance and non-fatal myocardial infarction across glycaemic states
Authors' conclusion
These results support the assumption that IR indexes based on anthropometrics and lipid panel, i.e., VAI and TG/HDL-C, could be a better measure of IR and CV-predictor for non-fatal MI in females, even without glycaemic perturbations.
Study context
- Population
- Participants free from known diabetes, categorized by OGTT as normal glucose tolerance, impaired fasting glucose, impaired glucose tolerance or newly diagnosed diabetes; 19% females, 81% males
- Participants
- 696 vs 707
- Comparison
- First non-fatal myocardial infarction (MI) vs no MI; Insulin resistance (IR) indexes by sex
- MI casesn = 696
- Without MIn = 707reference
- Outcome
- Association between IR indexes (HOMA-IR, VAI, TG/HDL-C index) and a first non-fatal MI by sex across glycaemic states
Main finding
As reported in the abstract
Association of IR indexes with first non-fatal MI, adjusted for major cardiovascular (CV) risk factors incl. sex
VAI and first non-fatal MI, females
OR 1.7, 1.0-2.9
95% CI
TG/HDL-C index and first non-fatal MI, females
OR 1.9, 1.1-3.4
95% CI
Observational data: associations, not effects.
Further findings
First non-fatal MI by sex
- Proportion of glycaemic states by sex · did not differ between the sexes
- P = 0.06
Insulin resistance by sex
- Females were less insulin resistant than males, especially among cases and with normal glucose tolerance
Original publication
Sex differences in the association between insulin resistance and non-fatal myocardial infarction across glycaemic states. Cardiovasc Diabetol. Published 13 January 2024. doi:10.
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