High Mannose Correlates With Surrogate Indexes of Insulin Resistance and Is Associated With an Increased Risk of Cardiovascular Events Independently of Glycemic Status and Traditional Risk Factors
Main finding · MACEResult — go to the resultHazard ratio 1.54 95% CI 1.07–2.20Authors' conclusion
Mannose might represent a new biomarker able to track early, potentially detrimental glucometabolic alterations independently of glycemic state.
Study context
- Population
- Participants, one-half with a first myocardial infarction (MI), with normal glucose tolerance or newly detected dysglycemia (IGT or T2D; n = 358)163 MACE · with normal glucose tolerance 1,045
- Participants
- 1,403 participants
- Exposure
- High vs low fasting mannose
- Outcome
- MACE
- Follow-up
- 10-year follow-up
Methodological details10-year follow-up
- 10-year follow-up
Main finding
As reported in the abstract
Hazard ratio
1.54
95% CI 1.07–2.20
High mannosevs Low mannose
HR 1.54 (95% CI 1.07–2.20)
Observational data: associations, not effects.
Further findings
Association of mannose with IR indexes
- Mannose independently associated with IR indexes
- all P ≤ 0.001
Original publication
High Mannose Correlates With Surrogate Indexes of Insulin Resistance and Is Associated With an Increased Risk of Cardiovascular Events Independently of Glycemic Status and Traditional Risk Factors. Diabetes Care. Published 6 December 2023. doi:10.
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