Changes in Isoleucine, Sarcosine, and Dimethylglycine During Oral Glucose Tolerance Test (OGTT) as Risk Factors for Diabetes
Authors' conclusion
Metabolic profiles differ after glucose induction in individuals with different glucose tolerance statuses. Changes in metabolite levels during OGTT are potential risk factors for diabetes development.
Study context
- Population
- Participants with different glucose tolerance statuses undergoing OGTT
- Comparison
- Normal glucose tolerance (NGT) vs impaired glucose regulation (IGR) vs newly diagnosed T2D
- Outcome
- Metabolite-level changes during OGTT and risk of diabetes and prediabetes
- Follow-up
- During OGTT
Methodological detailsOGTT with serum sampling at 0, 30, 60, 120 and 180 minutes, generalized estimating equation analysis
- OGTT with serum sampling at 0, 30, 60, 120 and 180 minutes
- Generalized estimating equation analysis
Main finding
As reported in the abstract
- Glucose intake increased glycolytic intermediates and decreased amino acids, glycerol, ketone bodies and TG
- Isoleucine levels differed between NGT and NDM and between NGT and IGR
- In the diabetes groups, changes in sarcosine during OGTT were opposite to those in glycine
- Isoleucine, sarcosine and acetic acid levels during OGTT associated with NDM risk (generalized estimating equation (GEE))
- Isoleucine and acetate levels during OGTT associated with IGR risk (GEE)
- Adjusted for sex, BMI, fasting insulin, heart rate, smoking status and blood pressure
Original publication
Changes in Isoleucine, Sarcosine, and Dimethylglycine During OGTT as Risk Factors for Diabetes. J Clin Endocrinol Metab. Published 12 January 2024. doi:10.
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