Circulating asprosin concentrations in individuals with new-onset type 2 diabetes and prediabetes
Authors' conclusion
This investigation revealed that individuals with prediabetes and those newly diagnosed with T2DM exhibit increased serum asprosin levels, suggesting that elevated asprosin concentrations are linked to early disturbances in glucose homeostasis.
Study context
- Population
- Adults aged 22–69 recruited from Jinan Central Hospital
- Participants
- 252 adults
- Exposure
- Serum asprosin in normal glucose tolerance (NGT) vs impaired glucose regulation (IGR) vs newly diagnosed T2D
- Outcome
- Serum asprosin levels (enzyme linked immunosorbent assay (ELISA))
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
As reported in the abstract
- Notable increase in serum asprosin in newly diagnosed T2DM; slightly elevated in IGR vs healthy group
- Progressive increase in proportion of IGR + T2DM across asprosin quartiles
Observational data: associations, not effects.
Further findings
ROC analysis of asprosin for identifying IGR + T2DM
- AUC
- 0.853 (95% CI 0.808-0.899)
- Asprosin threshold
- 4.95 ng/ml
Original publication
Circulating asprosin concentrations in individuals with new-onset type 2 diabetes and prediabetes. Diabetes Res Clin Pract. Published 10 June 2024. doi:10.
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