Moderate resistance training reduces intermuscular adipose tissue and risk factors of atherosclerotic cardiovascular disease for elderly patients with type 2 diabetes
Authors' conclusion
Low-level, moderate resistance training reduces IMAT content. Even a small reduction in IMAT may be related to a decrease in risk factors for atherosclerotic cardiovascular disease, but this small reduction may not be sufficient to reduce insulin resistance.
Study context
- Population
- Elderly patients with T2D37 per group completed
- Participants
- 85 patients
- Comparison
- Moderate resistance training vs control
- Resistance trainingn = 42
- Controln = 43reference
- Primary endpoint
- Change in IMAT measured by CT and MRI (IDEAL-IQ sequence)
- Follow-up
- 6 months
Primary result
As reported in the abstract
Change in IMAT area (CT)
| Group | Value | Baseline | End | % change |
|---|---|---|---|---|
| Resistance training | −0.512 ± 0.115 cm² | 5.176 ± 1.249 cm² | 4.660 ± 1.147 cm² | 9.89% decrease |
| Control | 0.587 ± 0.115 cm² | 10.34% increase |
Value
Resistance training−0.512 ± 0.115 cm²
Control0.587 ± 0.115 cm²
Baseline
Resistance training5.176 ± 1.249 cm²
Control— not stated in the abstract
End
Resistance training4.660 ± 1.147 cm²
Control— not stated in the abstract
% change
Resistance training9.89% decrease
Control10.34% increase
- Resistance training vs Control: significantly different — significantly different
Secondary outcomes
| Outcome | Resistance training | Control |
|---|---|---|
| Change in normal attenuation muscle area · 6 monthsSignificantly different | 1.049 ± 0.416 cm² | −1.113 ± 0.416 cm² |
| % change | 1.3% increase | 1.41% decrease |
| Change in HOMA2-β · 6 monthsSignificantly improved | 4.135 ± 1.910 | −3.457 ± 1.910 |
| % change | 7.91% increase | 6.05% decrease |
| Change in ∆I30/∆G30 (OGTT) · 6 monthsSignificantly improved | 0.715 ± 0.262 | −0.195 ± 0.262 |
| % change | 15.49% increase | 3.87% decrease |
Association of change in intermuscular adipose tissue (IMAT) with metabolic changes (adjusted linear regression)
- HOMA2-IR: β = −0.178
- P = 0.402
- HOMA2-β: β = −1.891
- P = 0.197
- ∆I30/∆G30: β = −0.439
- P = 0.047
- 2-h postprandial glucose: β = 1.321
- P = 0.026
- Diastolic BP: β = 2.425
- P = 0.018
- Normal attenuation muscle area: β = −0.907
- P = 0.019
- 10-year ASCVD risk: β = 0.976
- P = 0.002
- Adjusted for sex, age, diabetes duration, baseline IMAT and baseline dependent variable
Original publication
Moderate resistance training reduces intermuscular adipose tissue and risk factors of atherosclerotic cardiovascular disease for elderly patients with type 2 diabetes. Diabetes Obes Metab. Published 9 June 2024. doi:10.
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