Identification of adipose tissue‐derived exosomal micro RNA as a novel causal biomarker for cognitive impairment in type 2 diabetes mellitus: Triangulating evidence from Mendelian randomization and multicentre population studies
Authors' conclusion
Serum exosomal miR-125a-5p derived from adipose tissue can serve as a causal biomarker for cognitive impairment in T2DM patients.
Study context
- Population
- T2D patients; discovery: 6 T2D patients and 5 subjects with normal glucose tolerance; training population of 207 T2D patients; external population of 101 T2D patients from multiple centres
- Outcome
- Serum exosomal miRNAs as risk biomarkers for cognitive impairment in T2D
Methodological detailsdiscovery phase, validation phase, small RNA sequencing, Mendelian randomization using genome wide association studies (GWAS) datasets, training population, external multicentre validation
- Discovery phase
- Validation phase
- Small RNA sequencing
- Mendelian randomization using GWAS datasets
- Training population
- External multicentre validation
Performance
As reported in the abstract
- Discovery: exosomal microRNAs (miRNAs) significantly upregulated in adipose tissue of T2D patients
- 13
- Mendelian randomization (MR): increased miR-125a-5p causally associated with increased Alzheimer's disease (AD) risk, OR
- 1.231 (95% CI 1.062-1.426)
- Validation: higher serum exosomal miR-125a-5p and increased amnestic mild cognitive impairment (aMCI) risk, OR
- 1.066 (95% CI 1.030-1.103)
- Correlation with left hippocampal body volume (p < 0.05)
- r = −0.189
- AUC for identifying aMCI in T2D patients (training)
- 0.728
- AUC in external validation
- 0.738
Original publication
Identification of adipose tissue‐derived exosomal micro RNA as a novel causal biomarker for cognitive impairment in type 2 diabetes mellitus: Triangulating evidence from Mendelian randomization and multicentre population studies. Diabetes Obes Metab. Published 17 December 2024. doi:10.
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