Impact of physical fitness and exercise training on subcutaneous adipose tissue beiging markers in humans with and without diabetes and a high‐fat diet‐fed mouse model
Authors' conclusion
Higher physical fitness and different exercise interventions associated with higher gene expression levels of the beiging marker CD137 in healthy humans and mice on a high-fat diet. Humans with recent-onset type 2 diabetes show an impaired adipose tissue-specific response to physical activity.
Study context
- Population
- Humans with recent-onset T2D or without T2D, subcutaneous WAT (scWAT) biopsies; high-fat diet-fed FVB/N miceHumans with recent-onset T2D 28 · or without T2D 28
- Comparison
- High vs low physical fitness in humans with and without T2D; voluntary wheel running, treadmill training or no training in mice
- H-FITn = 14 each
- L-FITn = 14 eachreference
- Voluntary wheel runningn = 8
- Treadmill trainingn = 8
- No trainingn = 8reference
- Outcome
- Tnfrsf9/Cd137 expression in scWAT (humans)
Methodological detailshuman cross-sectional and mouse exercise intervention, stratified by spiroergometry, high-fat diet-fed FVB/N mice
- Human cross-sectional and mouse exercise intervention
- Stratified by spiroergometry
- High-fat diet-fed FVB/N mice
Main finding
As reported in the abstract
- CD137 expression higher in glucose-tolerant H-FIT than L-FIT
- three-fold
Further findings
scWAT beiging and mitochondria (mice)
- Both training modalities increased Cd137 expression and enhanced mitochondrial content without changing respiration in scWAT
Whole-body insulin sensitivity (mice)
- Improved with treadmill but not voluntary wheel running
Original publication
Impact of physical fitness and exercise training on subcutaneous adipose tissue beiging markers in humans with and without diabetes and a high‐fat diet‐fed mouse model. Diabetes Obes Metab. Published 23 October 2023. doi:10.
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