Fetuin B in white adipose tissue induces inflammation and is associated with peripheral insulin resistance in mice and humans
Authors' conclusion
Fetuin B content in white adipose tissue strongly associated with peripheral insulin resistance in mice and humans. Furthermore, fetuin B induced a proinflammatory response in adipocytes, which might drive peripheral insulin resistance.
Study context
- Population
- Mice, cultured adipocytes and humans
- Outcome
- Effects of fetuin B on white adipose tissue
Main finding
As reported in the abstract
- Fetuin B was produced and secreted by the liver and taken up by adipocytes and adipose tissue (adipocytes and mice)
- Strong negative correlation between white adipose tissue fetuin B content and peripheral insulin sensitivity (hyperinsulinemic-euglycemic clamp) in mice and humans
- Fetuin B induced an inflammatory response in adipocytes (RNA sequencing and PCR)
Original publication
Fetuin B in white adipose tissue induces inflammation and is associated with peripheral insulin resistance in mice and humans. Obesity (Silver Spring). Published 19 December 2023. doi:10.
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