Gender differences in midlife to later-life cumulative burden and variability of obesity measures and risk of all-cause and cause-specific mortality
Authors' conclusion
Cumulative burden and variability in general and central obesity measures were associated with higher all-cause and cardiovascular mortalities among men. In women, general obesity measures variability, as well as cumulative and variability of central adiposity measure, increased all-cause mortality risk.
Study context
- Population
- Atherosclerosis Risk in Communities (ARIC) study participants free of CVD, cancer and early mortality events; mean age 62.44,360 women
- Participants
- 7,615 participants
- Exposure
- Longitudinal cumulative burden (AUC) and variability (average successive variability (ASV)) of obesity measures, by gender
- Womenn = 4,360
- Outcome
- All-cause and cause-specific mortality
- Follow-up
- Median 16.9 years
Methodological detailssecondary analysis of ARIC study data, multivariable-adjusted Cox proportional hazard regression
- Secondary analysis of ARIC study data
- Multivariable-adjusted Cox proportional hazard regression
Main finding
As reported in the abstract
- Men: AUCs of waist-related obesity measures and ASVs of all obesity measures associated with increased all-cause mortality risk
- Women: waist circumference and waist-to-height ratio AUCs associated with increased all-cause mortality risk
- Cardiovascular mortality: all adiposity measures ASVs in both genders and waist-related obesity measures AUCs in men associated with increased risk
- Significant gender differences for cumulative and variability of waist-to-hip ratio (all-cause mortality) and all adiposity measures ASVs (cardiovascular mortality), with higher impact among men
- Multivariable-adjusted standardized HRs
Observational data: associations, not effects.
Original publication
Gender differences in midlife to later-life cumulative burden and variability of obesity measures and risk of all-cause and cause-specific mortality. Int J Obes (Lond). Published 19 December 2023. doi:10.
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