Adverse effect of obesity and dysglycemia on bone microarchitecture and strength in youth: sex-related differences
Authors' conclusion
There is a negative relationship between adiposity and insulin resistance with bone microarchitecture and strength in youth after accounting for age, sex, height, and lean mass. There appears to be sexual dimorphism in these relationships, with more negative effect of adiposity and dysglycemia on bone quality in males.
Study context
- Population
- Adolescents across the glycemia spectrum (56 females); 32% normal weight (NW), 29% overweight-normal glucose tolerance (OW-NGT), 39% OW-impaired glucose regulation (OW-IGR)56 females
- Participants
- 92 adolescents
- Exposure
- NW vs OW-NGT vs OW-IGR
- Outcome
- Bone quality (high-resolution peripheral quantitative CT), body composition and bone mineral content (BMC) (DXA)
Methodological detailssingle research center
- Single research center
Main finding
As reported in the abstract
Lean mass positively contributed to tibial volumetric BMD (vBMD) (multivariable model)
β = 3.9
P < .001
Height negatively contributed to tibial vBMD
β = −4.5
P < .001
HOMA-IR negatively contributed to tibial vBMD
β = −4.6
P = .005
Model variance explained, tibial vBMD
R2 = 0.45
P < .001
Observational data: associations, not effects.
Original publication
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