Exercise rehabilitation with tailored support for exercise adherence for people with vertebral fragility fractures is more effective than standard rehabilitation: the OPTIN randomised controlled trial
Authors' conclusion
This RCT found integrated, additional support for exercise behaviour within a programme of physiotherapy rehabilitation for people with VFF provided greater benefits to lower extremity function, balance and walking at 12 months as measured by the TUG and 6MW tests.
Study context
- Population
- People over 55 years with at least one vertebral fragility fracture and back pain57 intervention and 55 control analysed
- Participants
- 126 participants
- Comparison
- Exercise rehabilitation with integrated adherence support vs exercise rehabilitation alone
- Interventionn = 63
- Controln = 63reference
- Primary endpoint
- Timed-Up and Go (TUG)
- Follow-up
- 12 months
Methodological detailstwo-arm, individually randomised, concealed allocation, assessor blinding
- Two-arm
- Individually randomised
- Concealed allocation
- Assessor blinding
Primary result
TUG
Effect size
2.1 s
95% CI - 3.1 to - 1.0
P = 0.000
By group
Intervention
10.1
mean · SE 0.38 · seconds
Control
12.9
mean · s
As reported in the abstract
Secondary outcomes
| Outcome | Intervention | Control | Effect size (m) (95% CI) | P value |
|---|---|---|---|---|
| 6-min walk (6MW) · 12 months | mean 354.6 (SE 6.6) m | 325.7 (SE 6.9) m | 24.5 (5.7–43.4) | P = 0.011 |
QoL (QUALEFFO-41), thoracic kyphosis, functional reach, timed loaded standing · 12 months
- No significant differences in the other outcome measures
Safety
- No related adverse events
Original publication
Exercise rehabilitation with tailored support for exercise adherence for people with vertebral fragility fractures is more effective than standard rehabilitation: the OPTIN randomised controlled trial. Osteoporos Int. Published 30 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →