Comparative analysis of osteoporotic versus pathologic fracture in metastatic colorectal cancer patients
Authors' conclusion
The incidence rate of OF was comparable to that of PF and even higher in mCRC patients aged ≥ 70 years. While bone metastasis was a risk factor for PF, advanced age and osteoporosis were the risk factors for OF.
Study context
- Population
- Metastatic colorectal cancer (mCRC) patients who received palliative chemotherapy359 male
- Participants
- 622 patients
- Exposure
- Osteoporotic fracture vs pathologic fracture
- Outcome
- Incidence rates of and risk factors for OF and PF
- Follow-up
- 2 years
Methodological detailsconsecutive enrolment, multivariable analysis
- Consecutive enrolment
- Multivariable analysis
Main finding
As reported in the abstract
Cumulative incidence rate
Observational data: associations, not effects.
Further findings
| Outcome | Incidence rate ratio (95% CI) | |
|---|---|---|
| Crude incidence rate, patients aged ≥ 70 years (subgroup) | 4.65 (1.72–15.7) | |
| 0.050.21520Incidence rate ratio (log scale) |
Risk factors for osteoporotic fracture (OF) (multivariable, adjusted for bone and cancer-related variables)
- Older age, HR 1.04 (95% CI 1.00-1.08)
- P = 0.03
- Osteoporosis, HR 4.79 (95% CI 1.51-15.16)
- P = 0.01
Risk factors for PF
- Bone metastasis, HR 9.48 (95% CI 4.02-22.38)
- P < 0.01
Fracture events during follow-up
- Patients with fractures, 86 (13.8%); 96 fracture events
Original publication
Comparative analysis of osteoporotic versus pathologic fracture in metastatic colorectal cancer patients. Osteoporos Int. Published 30 June 2025. doi:10.
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