Disease severity-based subgrouping of type 2 diabetes does not parallel differences in quality of life: the Maastricht Study
Authors' conclusion
Disease severity suggested by the clusters of type 2 diabetes is not entirely reflected in quality of life. In particular, the MOD cluster does not appear to be moderate in terms of quality of life. Use of the suggested cluster names in practice should be carefully considered, as the non-neutral nomenclature may affect disease perception in individuals with type 2 diabetes and their healthcare providers.
Study context
- Population
- Individuals with T2D from the Maastricht Study, newly or already diagnosed127 newly, 585 already diagnosed
- Exposure
- T2D clusters: Moderate age-related diabetes (MARD) vs MOD vs severe insulin-deficient diabetes (SIDD) vs severe insulin-resistant diabetes (SIRD)
- Outcome
- Cluster characteristics and cluster-wise evolution of quality of life (SF-36)
- Follow-up
- 7 years
Methodological detailsclusters allocated by nearest centroid approach, separate analyses for newly and already diagnosed T2D
- Clusters allocated by nearest centroid approach
- Separate analyses for newly and already diagnosed T2D
Main finding
As reported in the abstract
Quality of life (SF-36)
- Few differences in SF-36 mental component score in both newly and already diagnosed
- MARD had a higher SF-36 physical component score than the other clusters in both groups
- MOD scored similarly to SIDD and SIRD on the physical component score
- Adjusted for age and sex (generalised estimating equations)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Reaching adequate glycaemic control, already diagnosedSIDDvs MARD | 0.31 (0.22–0.43) | |
| 0.20.5125Hazard ratio (log scale) |
- Reaching adequate glycaemic control, already diagnosed: SIDD less likely to reach glycaemic control than other clusters
Original publication
Disease severity-based subgrouping of type 2 diabetes does not parallel differences in quality of life: the Maastricht Study. Diabetologia. Published 11 January 2024. doi:10.
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