Effects of Exogenous GIP and GLP-2 on Bone Turnover in Individuals With Type 2 Diabetes
Authors' conclusion
Subcutaneous GIP and GLP-2 affect CTX and P1NP in individuals with T2D to the same extent as previously demonstrated in healthy individuals.
Study context
- Population
- Men with T2D, fasting, 3 separate test daysmen with T2D
- Participants
- 10 men
- Comparison
- Subcutaneous GIP vs GLP-2 vs placebo
- GIPn = 10
- GLP-2n = 10
- Placebon = 10reference
- Primary endpoint
- Bone turnover: circulating CTX, P1NP, sclerostin and PTH
Methodological detailsrandomized crossover, placebo-controlled
- Randomized crossover
- Placebo-controlled
Primary result
As reported in the abstract
CTX, % of baseline
P = 0.001
Further findings
Mean, % of baseline
| Outcome | GIP | GLP-2 |
|---|---|---|
| PTH, % of baseline | 86 (SE 3.4) | 67 (SE 2.5) |
P1NP and sclerostin
- P1NP and sclerostin increased acutely after GIP
- Decrease in P1NP after GLP-2
Original publication
Effects of Exogenous GIP and GLP-2 on Bone Turnover in Individuals With Type 2 Diabetes. J Clin Endocrinol Metab. Published 13 January 2024. doi:10.
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