The Separate and Combined Effects of GIP, GLP-1, and GLP-2 on Markers of Bone Turnover in Type 2 Diabetes
Authors' conclusion
Our findings suggest that postprandial suppression of bone resorption in individuals with T2D is mediated by the additive effects of GIP, GLP-1, and GLP-2.
Study context
- Population
- Individuals with T2Dcrossover
- Participants
- 10 individuals
- Comparison
- Oral glucose tolerance test (OGTT) vs isoglycaemic IV glucose infusions (IIGI) with saline, GIP, GLP-1, GLP-2, and GIP + GLP-1 + GLP-2 infusions
- Primary endpoint
- Changes in plasma β-CTX-I and PINP
Methodological detailsrandomized, 6 experimental days
- Randomized
- 6 experimental days
Primary result
As reported in the abstract
- β-CTX-I significantly suppressed during OGTT vs IIGI
- IIGI with GIP + GLP-1 + GLP-2 suppressed β-CTX-I comparably to OGTT
- No reduction in PINP during IIGI with GIP, GLP-1, and GIP + GLP-1 + GLP-2
- PINP significantly reduced during OGTT and during IIGIs with saline and with GLP-2
Original publication
The Separate and Combined Effects of GIP, GLP-1, and GLP-2 on Markers of Bone Turnover in Type 2 Diabetes. J Clin Endocrinol Metab. Published 29 August 2025. doi:10.
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