GIP contributes to postprandial regulation of splanchnic blood supply in humans with type 2 diabetes: a randomised, single-blinded, placebo-controlled, crossover study
Primary result · Mean blood flow in arteria mesenterica superiorResult — go to the resultDifference 15 % 95% CI −2 to 32Authors' conclusion
Endogenous GIP contributes to postprandially increased splanchnic blood flow in people with type 2 diabetes.
Study context
- Population
- Participants with T2D, age 20–80 years, BMI 20–35 kg/m², HbA1c >48 mmol/mol and <75 mmol/mol; Rigshospitalet, Copenhagencrossover, 4 occasions
- Participants
- 10 participants
- Comparison
- Oral glucose + i.v. GIPNH2 vs oral glucose + i.v. saline
- Primary endpoint
- Changes in blood flow in arteria mesenterica superior (phase-contrast MRI) during oral glucose with or without GIP receptor antagonist infusion
Methodological detailscrossover, single-blinded, placebo-controlled, single-centre, Participants unaware of allocation, investigators aware; randomisation via random.org
- Crossover
- Single-blinded
- Placebo-controlled
- Single-centre
- Participants unaware of allocation, investigators aware; randomisation via random.org
Primary result
Mean blood flow in arteria mesenterica superior
Difference
15 %
95% CI −2 to 32
P = 0.012
Glucose + GIP(3-30)NH2vs Glucose + saline
difference 15 % (95% CI −2 to 32); P = 0.012
As reported in the abstract
- Oral glucose alone increased mean blood flow in arteria mesenterica superior
- 57% (95% CI 26, 88)
Further findings
Insulin secretion, C-peptide, C-peptide/glucose ratio, glucagon, plasma glucose
- GIP receptor antagonist during oral glucose lowered insulin secretion, C-peptide and C-peptide/glucose ratio vs saline; glucagon and plasma glucose unaffected
Oral water
- Oral water did not affect any outcomes
Original publication
GIP contributes to postprandial regulation of splanchnic blood supply in humans with type 2 diabetes: a randomised, single-blinded, placebo-controlled, crossover study. Diabetologia. Published 2 July 2026. doi:10.
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