Disentangling the effect of brain insulin resistance on brain health ( brain insulin resistance (BIR) ‐ BrainHealth ): Rationale and study protocol
Study context
- Population
- Adults with T1D, T2D and without diabetes, Denmark and Germanyplanned recruitment
- Participants
- 150 adults
- Planned comparison
- T1D vs T2D vs no diabetes
- Type 1 diabetesn = ≈50
- Type 2 diabetesn = ≈50
- Without diabetesn = ≈50reference
- Primary endpoint
- Brain insulin response: cerebral blood flow changes to intranasal insulin measured by perfusion-weighted MRI
Methodological detailsmulticentre, baseline cross-sectional analyses, Metabolic and cognitive phenotyping, multimodal neuroimaging, biomarker profiling; MRI of cerebrovascular reactivity, neurovascular coupling, blood-brain barrier integrity and hypothalamic responses during OGTT; blood, urine and faecal biobank
- Multicentre
- Baseline cross-sectional analyses
- Metabolic and cognitive phenotyping, multimodal neuroimaging, biomarker profiling; MRI of cerebrovascular reactivity, neurovascular coupling, blood-brain barrier integrity and hypothalamic responses during OGTT; blood, urine and faecal biobank
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Disentangling the effect of brain insulin resistance on brain health ( BIR ‐ BrainHealth ): Rationale and study protocol. Diabet Med. Published 2 July 2026. doi:10.
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