The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans
Authors' conclusion
GIP(1-30)NH2 has similar effects on glucose and bone metabolism in healthy individuals and in human islets in vitro as GIP(1-42).
Study context
- Population
- Healthy men; and isolated human pancreatic isletscrossover
- Participants
- 9 men
- Comparison
- GIPNH2 vs GIP vs saline
Methodological detailsthree-step glucose clamps, randomised order, in vitro human islet experiments
- Three-step glucose clamps
- Randomised order
- In vitro human islet experiments
Primary result
As reported in the abstract
Glucose and bone metabolism
- Compared to placebo, GIP(1-30)NH2 had similar glucagonotropic, insulinotropic and CTX-suppressing effects as GIP(1-42)
- In human islets in vitro, similar insulinotropic and glucagonotropic effects of the two GIP variants
Further findings
Glucose infused to obtain PG at FPG, 1.5× FPG and 2× FPG — between GIP(1-42) and Saline · across the three days
P = 0.18
Glucose infused to obtain plasma glucose (PG) at fasting plasma glucose (FPG), 1.5× FPG and 2× FPG
- PG levels similar on the three experimental days
Original publication
The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans. Eur J Endocrinol. Published 10 January 2023. doi:10.
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