Acute GIP and GLP ‐1 Administration Exerts Differential Metabolic Effects in Totally Pancreatectomised Individuals
Primary result · Postprandial glucose excursionsResult — go to the resultReduction 45%Authors' conclusion
Physiological actions of GIP and GLP-1 were preserved in totally pancreatectomised individuals, demonstrating independency of endogenous pancreatic factors.
Study context
- Population
- Totally pancreatectomised individuals (5 women; mean age 58.8 ± 13.9 years; BMI 24.7 ± 5.1 kg/m²), continuing basal insulin4 meal tests each
- Participants
- 12 participants
- Comparison
- IV GIP, GLP-1 and GIP+GLP-1 vs saline during mixed meal tests
Methodological detailsdouble-blind, placebo-controlled, Participants continued basal insulin but omitted other medications incl. bolus insulin from 10 p.m. the night before
- Double-blind
- Placebo-controlled
- Participants continued basal insulin but omitted other medications incl. bolus insulin from 10 p.m. the night before
Primary result
Postprandial glucose excursions
Reduction
45%
P = 0.005
As reported in the abstract
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Gastric emptying rate (acetaminophen absorption)GLP-1 vs Placebo · ± 36% | reduction 29% | P = 0.05 |
| Ad libitum food intakeGIP+GLP-1 vs Placebo · ± 22% | lower 31% | P = 0.018 |
| Heart rateGIP vs Placebo · ± 5.9 | increase 10 bpm | P = 0.004 |
| Diastolic blood pressureGIP vs Placebo · ± 5.4 | decrease 9.1 bpm | P = 0.002 |
| Postprandial bone resorption (CTX)GIP vs Placebo · ± 35% | inhibition 65% | P = 0.003 |
Gastric emptying rate (acetaminophen absorption)
- Effects of GIP were similar to placebo
Ad libitum food intake
- GIP+GLP-1 similar to GLP-1 infusion
Postprandial bone resorption (CTX)
- GLP-1 infusion did not affect bone resorption markers
Original publication
Acute GIP and GLP ‐1 Administration Exerts Differential Metabolic Effects in Totally Pancreatectomised Individuals. Diabetes Obes Metab. Published 1 June 2026. doi:10.
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