Role of Sex Hormones in Mediating Adiposity Changes From Weight Loss in People With Type 2 Diabetes: Look AHEAD Sex Hormone Study
Authors' conclusion
This study revealed sex-specific mediating effects of sex hormones due to weight loss from ILI on body composition changes in people with T2D. Further research is needed to explore long-term health outcomes related to sex differences in recommendations for weight loss in people with T2D.
Study context
- Population
- People with T2D in the Look AHEAD Sex Hormone Ancillary Study (50% female)822 with DXA
- Participants
- 2,334 people
- Comparison
- Intensive lifestyle intervention (ILI)-associated changes in sex hormones at Y1 as mediators of adiposity changes at Y4
- Primary endpoint
- Mediation by changes in E2, T and SHBG at Y1 of the effects of ILI on adiposity measures
- Follow-up
- Y4
Methodological detailsSex Hormone Ancillary Study, structural equation modeling, stratified by sex
- Sex Hormone Ancillary Study
- Structural equation modeling
- Stratified by sex
Primary result
As reported in the abstract
Mediating effects of sex hormone changes on adiposity at Y4
- Men: 14.4% ILI-associated increase in total T at Y1 mediated increase in weight
- 189 g (95% CI, 65-317)
- Men: total T increase mediated increase in waist circumference
- 0.135 cm (95% CI, 0.19-0.248)
- Men: 24.6% increase in SHBG at Y1 mediated increase in % trunk fat
- 0.082% (95% CI, 0.003%-0.174%)
- Men: SHBG increase mediated increase in % whole-body fat
- 0.068% (95% CI, 0.001%-0.146%)
- Women: 21.8% decrease in bioavailable T (BioT) at Y1 mediated decrease in whole-body fat mass
- −164 (95% CI, −326 to −29.3)
- Women: BioT decrease mediated decrease in whole-body lean mass
- −115 g (95% CI, −203.4 to −40)
- Women: BioT decrease mediated decrease in trunk lean mass
- −97.2 g (95% CI, −156 to −45.5)
Original publication
Role of Sex Hormones in Mediating Adiposity Changes From Weight Loss in People With Type 2 Diabetes: Look AHEAD Sex Hormone Study. J Clin Endocrinol Metab. Published 20 May 2025. doi:10.
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