Effects of Genetic Risk on Incident Type 2 Diabetes and Glycemia: The T2D-GENE Lifestyle Intervention Trial
Authors' conclusion
Our results showed that individuals with a high genetic risk for T2D benefitted from a low-cost group-based intervention focusing on healthy diet and physical activity. Therefore, all individuals at risk of T2D should be encouraged to make lifestyle changes regardless of genetic risk.
Study context
- Population
- Men from the Metabolic Syndrome in Men (METSIM) cohort, aged 50–75 years, BMI ≥25 kg/m², FPG 5.6–6.9 mmol/L, HbA1c < 48 mmol/mol, with a low or high genetic risk score for T2D
- Participants
- 973 men
- Comparison
- Group-based lifestyle intervention vs control, by low or high genetic risk for T2D
- Intervention, low genetic riskn = 315
- Intervention, high genetic riskn = 313
- Control, low genetic riskn = 196reference
- Control, high genetic riskn = 149reference
- Primary endpoint
- Incident T2D
Methodological detailsgroup-based lifestyle intervention, population-based control groups, 3-year intervention
- Group-based lifestyle intervention
- Population-based control groups
- 3-year intervention
Primary result
As reported in the abstract
Hazard ratio (95% CI)P value
Intervention, high genetic riskvs Control, high genetic risk
0.30(0.16–0.56)
P < 0.001Intervention, low genetic riskvs Control, low genetic risk
0.69(0.36–1.32)
P = 0.262- Intervention effect not significantly different between high and low genetic risk groups
- P = 0.135
Secondary outcomes
- Intervention significantly ameliorated worsening of glycemia and decreased weight in both low and high genetic risk groups
Original publication
Effects of Genetic Risk on Incident Type 2 Diabetes and Glycemia: The T2D-GENE Lifestyle Intervention Trial. J Clin Endocrinol Metab. Published 18 June 2024. doi:10.
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