HbA1c-defined prediabetes and progression to type 2 diabetes in Denmark: A population-based study based on routine clinical care laboratory data
Authors' conclusion
Out of 100 Danish adults, 1.4 develop prediabetes each year and they can be identified at an early stage in laboratory databases. Within five years, one in five individuals with prediabetes progresses to diabetes and one in six dies.
Study context
- Population
- Adult Danes with HbA1c measurements from general practice and hospitals, 2012–2018; prediabetes defined as HbA1c 42–47 mmol/moladult Danes
- Participants
- 4,979,590 danes
- Outcome
- Prevalence, incidence, mortality and risk of progression to T2D in HbA1c-defined prediabetes
Methodological detailsnationwide, routine clinical care laboratory data, death as competing event
- Nationwide
- Routine clinical care laboratory data
- Death as competing event
Main finding
As reported in the abstract
Prediabetes prevalence, incidence and progression
- ≥1 HbA1c measurement during 2012 to 2018
- 70.8% (95% CI 70.8-70.9)
- Prevalence of prediabetes in 2018
- 7.1% (95% CI 7.1-7.1)
- Incidence rate of prediabetes per 1,000 person-years
- 14.2 (95% CI 14.1-14.3)
- Died within five years
- 17.5% (95% CI 17.3-17.7)
- 5-year cumulative incidence of T2D, death as competing event
- 21.3% (95% CI 21.1-21.5)
Observational data: associations, not effects.
Further findings
Characteristics at prediabetes diagnosis
- Median age, years (IQR 56.7-75.7)
- 66.9
- Median HbA1c, mmol/mol (IQR 42-44)
- 43
Original publication
HbA1c-defined prediabetes and progression to type 2 diabetes in Denmark: A population-based study based on routine clinical care laboratory data. Diabetes Res Clin Pract. Published 13 July 2023. doi:10.
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