Insulin growth factor axis and cardio-renal risk in diabetic kidney disease: an analysis from the CREDENCE trial
Primary result · Primary composite outcomeResult — go to the resultHazard ratio 1.52 95% CI 1.09–2.13Authors' conclusion
These results further suggest potential importance of IGF biology in the risk for cardio-renal outcomes in type 2 diabetes. SGLT2 inhibition has no impact on the biology of IGF despite its significant influence on outcomes.
Study context
- Population
- Individuals with T2D and CKD randomized to canagliflozin or placebo in CREDENCE, with samples available
- Participants
- 2,627 individuals
- Comparison
- Elevated vs non-elevated IGF-1
- Primary endpoint
- Composite of:
- End-stage kidney disease
- Doubling of serum creatinine
- Renal/cardiovascular death
Methodological detailsbiomarker analysis, multivariable Cox proportional hazard regression
- Biomarker analysis
- Multivariable Cox proportional hazard regression
Primary result
Primary composite outcome
Hazard ratio
1.52
95% CI 1.09–2.13
P: 0.01
By group
Elevated IGF-1vs Non-elevated IGF-1
HR 1.52 (95% CI 1.09–2.13); P: 0.01
As reported in the abstract
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Renal composite outcome | 1.65 (1.14–2.41) | P: 0.01 | |
| All-cause mortality | 1.52 (1.00–2.32) | P; 0.05 | |
| 0.512Hazard ratio (log scale) |
Log IGF-1/IGFBP-3 ratio and primary composite outcome
- HR per unit increase
- 1.57 (95% CI 1.09-2.26; P; 0.01)
Log IGFBP-3 and clinical outcomes
- Elevations in log IGFBP-3 did not associate with any clinical outcomes
Effect of canagliflozin on IGF-1 and IGFBP-3 · 3 years
- Canagliflozin did not significantly change IGF-1 and IGFBP-3 concentrations
- P > 0.05
eGFR at baseline
- Elevated IGF-1 associated with lower glomerular filtration rate
Original publication
Insulin growth factor axis and cardio-renal risk in diabetic kidney disease: an analysis from the CREDENCE trial. Cardiovasc Diabetol. Published 12 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →