Extremes of both weight gain and weight loss are associated with increased incidence of heart failure and cardiovascular death: evidence from the CANVAS Program and CREDENCE
Authors' conclusion
Extremes of weight gain or loss were independently associated with a higher risk of the composite of hHF and CV death.
Study context
- Population
- Patients with T2D and high cardiovascular (CV) risk in the CANVAS Program and CREDENCE trials of canagliflozin
- Comparison
- Extreme weight gain or weight loss vs stable weight
- Primary endpoint
- hHF and the composite of hHF and CV death
Methodological detailspost hoc pooled cohort of two RCTs of canagliflozin, univariate and multivariate Cox proportional hazards models
- Post hoc pooled cohort of two RCTs of canagliflozin
- Univariate and multivariate Cox proportional hazards models
Primary result
As reported in the abstract
hHF/CV death (multivariate analysis)
Each group vs stableEstimate (95% CI)
GainersCANVAS
HR 1.61(1.20–2.16)
LosersCANVAS
HR 1.53(1.14–2.03)
GainersCREDENCE
adjusted HR 1.62(1.19–2.16)
Further findings
Median, kg
| Outcome | Gainers | Losers |
|---|---|---|
| Magnitude of weight change · randomization to week 52-78Gain in gainers, loss in losers | 4.5 | 8.5 |
Magnitude of weight change · randomization to week 52-78
- Weight change within each category only slightly larger with canagliflozin than placebo
Original publication
Extremes of both weight gain and weight loss are associated with increased incidence of heart failure and cardiovascular death: evidence from the CANVAS Program and CREDENCE. Cardiovasc Diabetol. Published 29 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →