Hyperinsulinemia and plasma glucose level independently associated with all-cause and cardiovascular mortality in Chinese people without diabetes—A post-hoc analysis of the 30-year follow-up of Da Qing diabetes and IGT study
Authors' conclusion
In this post-hoc study, participants with either high glucose or high insulin were related to increased risk of mortality, implying that strategies targeting eliminating both hyperglycemia and hyperinsulinemia may favor the long-term outcomes.
Study context
- Population
- Individuals without diabetes in the original Da Qing Diabetes and IGT Study; groups by medians of baseline glucose and insulin
- Participants
- 462 individuals
- Comparison
- Insulin/glucose groups vs low insulin low glucose
- Primary endpoint
- All-cause and cardiovascular disease (CVD) death
- Follow-up
- 1986 to 2016
Methodological detailscovariate-adjusted
- Covariate-adjusted
Primary result
As reported in the abstract
All-cause death · 30-year follow-up
Each group vs G1Hazard ratio (95% CI)
G2
1.65(1.02–2.67)
G3
1.76(1.11–2.81)
G4
2.32(1.45–3.69)
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD death · 30-year follow-upG2vs G1Adjusted for covariates | 2.03 (1.01–4.05) | |
| CVD death · 30-year follow-upG3vs G1Adjusted for covariates | 1.85 (0.93–3.68) | |
| CVD death · 30-year follow-upG4vs G1Adjusted for covariates | 2.68 (1.35–5.29) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Hyperinsulinemia and plasma glucose level independently associated with all-cause and cardiovascular mortality in Chinese people without diabetes—A post-hoc analysis of the 30-year follow-up of Da Qing diabetes and IGT study. Diabetes Res Clin Pract. Published 5 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →