Plasma Endocannabinoids Are Independently Associated With the Metabolic Function of White Adipose Tissue
Authors' conclusion
EC levels of the NAE family independently follow plasma NEFA metabolism, whereas 2-MAG closely follow the spillover of triglyceride-rich lipoprotein intravascular lipolytic products. Whether these associations are causal requires further investigation.
Study context
- Population
- Men and women with or without impaired glucose tolerance
- Participants
- 20 vs 20
- Comparison
- IGT vs NGT
- IGTn = 20
- NGTn = 20reference
- Outcome
- Link of plasma ECs with postprandial fatty acid metabolism and white adipose tissue (WAT) metabolic function
Methodological detailsstable isotope palmitate tracers, positron emission tomography, meal testing
- Stable isotope palmitate tracers
- Positron emission tomography
- Meal testing
Main finding
As reported in the abstract
- Postprandial AUC of palmitate appearance rate independently associated with postprandial AUC of anandamide (AEA)
- P = .0003
- Postprandial AUC of palmitate appearance rate independently associated with total energy expenditure
- P = .0009
- Dietary fatty acid (DFA) storage in abdominal subcutaneous adipose tissue positively predicted by fasting 2-AG
- P < .04
Original publication
Plasma Endocannabinoids Are Independently Associated With the Metabolic Function of White Adipose Tissue. J Clin Endocrinol Metab. Published 19 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →