Association of remnant cholesterol with stroke risk by glycemic status: a nationwide prospective cohort study
Authors' conclusion
In individuals with Pre-DM and DM, higher RC independently predicts incident stroke, especially when LDL-C is <130 mg/dL, supporting RC as a potential target after LDL-C goals are achieved.
Study context
- Population
- Participants aged ≥45 years without prior stroke, China Health and Retirement Longitudinal Study (CHARLS)
- Participants
- 9,182 participants
- Exposure
- Remnant cholesterol (RC) quartiles 2–4 vs lowest RC quartile
- Outcome
- Incident self-reported stroke
- Follow-up
- Over 7 years
Methodological detailsnationwide, CHARLS
- Nationwide
- CHARLS
Main finding
As reported in the abstract
Incident stroke, overall cohort
Hazard ratio (95% CI)
Q2vs Q1
1.228(0.980–1.537)
Q3vs Q1
1.390(1.116–1.730)
Q4vs Q1
1.419(1.138–1.769)
- Developed stroke during follow-up
- 867 (9.44%)
Observational data: associations, not effects.
Further findings
Stroke by glycemic status
- Stroke risk increased across RC quartiles in Pre-DM and diabetes mellitus (DM), but not in normal glucose regulation (NGR)
Stroke by low-density lipoprotein cholesterol (LDL-C) threshold (130 mg/dL)
- Associations stronger when LDL-C <130 mg/dL; significant in Pre-DM and DM but not in NGR
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of remnant cholesterol with stroke risk by glycemic status: a nationwide prospective cohort study. Diabetes Res Clin Pract. Published 24 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →