Physical Activity Changes and the Risk of Incident Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus: A Nationwide Longitudinal Follow-up Cohort Study of 1.8 Million Subjects
Authors' conclusion
In patients with T2DM, starting and maintaining regular PA were both associated with lower risk of incident AF. Optimal PA ranges based on energy expenditure, which were associated with lower risks of incident AF, can be defined.
Study context
- Population
- Patients with T2D without history of AF who underwent health examinations twice at a 2-year interval between 2009 and 2012; followed until 2018
- Participants
- 1,815,330 patients
- Exposure
- Regular physical activity (PA) alteration categories vs persistent nonexercisers
- Persistent nonexercisersn = 1,181,837reference
- New exercisersn = 242,968
- Exercise dropoutsn = 225,124
- Exercise maintainersn = 165,401
- Outcome
- Incident AF
- Follow-up
- Mean 5.6 ± 1.3 years
Methodological detailsnationwide database
- Nationwide database
Main finding
As reported in the abstract
Each group vs persistent nonexercisersEstimate (95% CI)
Exercise dropouts
aHR 0.96(0.94–0.99)
New exercisers
HR 0.95(0.93–0.98)
Exercise maintainerslowest risk
HR 0.91(0.89–0.94)
- New-onset AF cases overall
- 46,589 (2.6%)
Observational data: associations, not effects.
Further findings
Incident AF by energy expenditure
- Regular PA ≥1,500 MET-min/week in new exercisers and ≥1,000 MET-min/week in exercise maintainers associated with lower risk of incident AF vs nonexercisers
Original publication
Physical Activity Changes and the Risk of Incident Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus: A Nationwide Longitudinal Follow-up Cohort Study of 1.8 Million Subjects. Diabetes Care. Published 5 December 2022. doi:10.
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