Association of Complement C3 With Incident Type 2 Diabetes and the Mediating Role of Body Mass Index (BMI): A 10-Year Follow-Up Study
Main finding · Incident T2DResult — go to the resultHazard ratio 1.52 95% CI 1.14–2.02Authors' conclusion
The present prospective study revealed that C3 could be an early biomarker for incident T2DM, and that BMI might play a potential mediating role in the C3-T2DM associations, which provided clues for the pathogenesis of diabetes.
Study context
- Population
- Nondiabetic middle-aged and elderly individuals (64.62 ± 7.25 years), Dongfeng-Tongji cohort
- Participants
- 2,662 participants
- Exposure
- Serum C3 levels
- Outcome
- Incident T2D
- Follow-up
- 10 years
Methodological details10-year follow-up, Cox regression, mediation analysis
- 10-year follow-up
- Cox regression
- Mediation analysis
Main finding
As reported in the abstract
23 067 person-years of follow-up
Hazard ratio
1.52
95% CI 1.14–2.02
P = 0.029 for trend
Q4vs Q1
HR 1.52 (95% CI 1.14–2.02); P for trend = 0.029
- Developed T2D
- 711 (26.7%)
- HR per SD higher serum C3, after full adjustment
- 1.16 (95% CI 1.05, 1.27)
Observational data: associations, not effects.
Further findings
Dose-response relationship between C3 levels and BMI
- Robust significant linear dose-response relationship
- Poverall < 0.001, Pnonlinear = 0.96
Mediation by BMI of C3-T2D association
- BMI might mediate share of C3-T2D associations
- 41.0%
Original publication
Association of Complement C3 With Incident Type 2 Diabetes and the Mediating Role of BMI: A 10-Year Follow-Up Study. J Clin Endocrinol Metab. Published 7 October 2022. doi:10.
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