Atherogenic index of plasma, high sensitivity C-reactive protein and incident diabetes among middle-aged and elderly adults in China: a national cohort study
Authors' conclusion
This cohort suggests combined effects and mutual mediation between the AIP and hsCRP on incident diabetes in China. Our findings provide clinical implications for monitoring and managing AIP and hsCRP levels to mitigate the development of diabetes.
Study context
- Population
- Adults aged ≥45 years free of diabetes at baseline in 2011, 125 cities in China5,048 followed up
- Participants
- 9,112 adults
- Exposure
- Highest vs lowest quartile of atherogenic index of plasma (AIP) and high-sensitivity C-reactive protein (hsCRP)
- Outcome
- Incident diabetes
- Follow-up
- Four years
Methodological detailsnationally representative, China Health and Retirement Longitudinal Study
- Nationally representative
- China Health and Retirement Longitudinal Study
Main finding
As reported in the abstract
Adjusted odds ratio (95% CI)
Highest quartile of AIPvs Lowest quartile of AIP
2.53(1.90–3.38)
Highest quartile of hsCRPvs Lowest quartile of hsCRP
2.38(1.79–3.16)
- Developed diabetes (overall)
- 489 (9.7%)
- Joint effect: higher AIP and higher hsCRP, aOR
- 2.76 (2.13-3.57)
Observational data: associations, not effects.
Further findings
Glycaemic biomarkers (linear mixed-effect (LME) models)
- AIP and hsCRP related to increased fasting blood glucose and HbA1c
Prediction of incident diabetes
- AUC, AIP + hsCRP combined (better than either alone)
- 0.628, 0.601-0.654
Mediation analysis
- AIP mediated share of hsCRP–diabetes association
- 25.4%
- hsCRP mediated share of AIP–diabetes association
- 5.7%
Original publication
Atherogenic index of plasma, high sensitivity C-reactive protein and incident diabetes among middle-aged and elderly adults in China: a national cohort study. Cardiovasc Diabetol. Published 5 March 2025. doi:10.
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