Aortic valve calcification across stages of dysglycemia in middle-aged individuals from the general population
Authors' conclusion
In this large, contemporary, and randomly selected population of middle-aged individuals, prediabetes, newly detected diabetes and known diabetes were all associated with CT-detected AVC. Further studies are warranted to investigate if managing dysglycemia, even in its early stages, may help slow down AVC progression.
Study context
- Population
- Middle-aged men and women from the general population, Swedish CArdioPulmonary bioImage Study (SCAPIS), 6 sites in Sweden, 2013–2018; mean age 57.5 years30,154 enrolled
- Participants
- 29,331 men
- Exposure
- Prediabetes, newly detected diabetes and known diabetes vs normoglycemia
- Outcome
- AVC (evident or not) on cardiac computed tomography (CT)
Methodological detailspopulation-based, random sampling, multicentre (six study sites)
- Population-based
- Random sampling
- Multicentre (six study sites)
Main finding
As reported in the abstract
AVC, adjusted for age, sex, smoking, study site, LDL-C and hypertension
Each group vs normoglycemiaOdds ratio (95% CI)
Prediabetes
1.16(1.02–1.31)
Newly detected diabetes
1.34(1.05–1.71)
Known diabetes
1.61(1.34–1.93)
Observational data: associations, not effects.
Further findings
Aortic valve calcification (AVC) prevalence across glycemic categories, males
- AVC prevalence increased progressively across glycemic categories, particularly in males
- P < 0.01
AVC prevalence across glycemic categories, females
- AVC prevalence increased progressively across glycemic categories in females, less than in males
- P < 0.01
Original publication
Aortic valve calcification across stages of dysglycemia in middle-aged individuals from the general population. Cardiovasc Diabetol. Published 5 March 2025. doi:10.
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