Identification of Gut Microbiome Signatures and Metabolites Associated With Albuminuria in Type 2 Diabetes
Authors' conclusion
These findings provide additional evidence of the potential impact of microbial species and contribute to our understanding of the complex relationship between the gut microbiome, plasma metabolites, and albuminuria in individuals with diabetes.
Study context
- Population
- Participants with T2D from the Swedish CArdioPulmonary BioImage Study (SCAPIS); replication in a prediabetic population in SCAPIST2D, SCAPIS · replication in a prediabetic population 3,423
- Participants
- 752 participants
- Outcome
- Association of 1002 gut microbial species and 1308 plasma metabolites with albuminuria
Methodological detailsdeep shotgun metagenomic sequencing, mass spectrometry-based metabolomics, independent replication cohort
- Deep shotgun metagenomic sequencing
- Mass spectrometry-based metabolomics
- Independent replication cohort
Main finding
As reported in the abstract
Gut microbial species associated with albuminuria
Species associated with albuminuria (Sellimonas intestinalis, Eggerthellales sp., Ellagibacter isourolithinifaciens)
3
Species replicated in an independent prediabetic population (n = 3423)
2
Annotated metabolites associated with the 3 albuminuria-signature species
36
Observational data: associations, not effects.
Further findings
Functional mapping of signature species
- Suggests a role in regulation of imidazole propionate and trigonelline, previously reported to play roles in albuminuria progression
Original publication
Identification of Gut Microbiome Signatures and Metabolites Associated With Albuminuria in Type 2 Diabetes. J Clin Endocrinol Metab. Published 14 August 2025. doi:10.
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