Impaired microcirculation in the skin and subclinical atherosclerosis in individuals with dysglycaemia in a large population-based cohort
Authors' conclusion
Patients with prediabetes and diabetes are more likely to have impaired microcirculation in the forearm skin and macrovascular disorders such as arterial stiffness and atherosclerosis in the coronary arteries compared to normoglycaemic individuals.
Study context
- Population
- Participants aged 50–65 years with microcirculatory measurements and glycaemic status, Linköping site of the Swedish CArdio-Pulmonary bioImage Study (SCAPIS)
- Participants
- 3,300 participants
- Exposure
- Prediabetes and diabetes vs normoglycaemia
- Outcome
- Prevalence of impaired microcirculation (forearm skin peak blood oxygen saturation, OxyP), coronary atherosclerosis (CACS) and arterial stiffness (PWV)
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
Skin microvascular function: peak blood oxygen saturation (OxyP)
Each group vs normoglycaemiaDifference, %-units (95% CI)
Prediabetes
−1.2(−1.8 to −0.6)
Diabetes
−2.4(−3.1 to −1.6)
- OxyP in normoglycaemic group
- 84.3%, 95% CI (83.6 to 84.9)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Impaired function at three vascular levels (lowest quartile of OxyP + PWV ≥ 10 m/s and CACS ≥ 100)Between Normoglycaemia and Diabetes · significant difference | P = < 0.05 |
| Impaired function at three vascular levels (lowest quartile of OxyP + PWV ≥ 10 m/s and CACS ≥ 100)Between Prediabetes and Diabetes · significant difference | P = < 0.05 |
Pulse wave velocity (PWV) and Coronary Artery Calcification Score (CACS)
- PWV and CACS were higher in participants with dysglycaemia
Original publication
Impaired microcirculation in the skin and subclinical atherosclerosis in individuals with dysglycaemia in a large population-based cohort. Cardiovasc Diabetol. Published 21 February 2025. doi:10.
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