Prevalence of atherosclerosis in individuals with prediabetes and diabetes compared to normoglycaemic individuals—a Swedish population-based study
Authors' conclusion
In this large population-based cohort of currently asymptomatic people, the atherosclerotic burden in the coronary and carotid arteries increased with increasing degree of dysglycaemia. The finding that the atherosclerotic burden in the coronary arteries in the undetected diabetes category was midway between the prediabetes category and patients with known diabetes may have implications for screening strategies and tailored prevention interventions for people with dysglycaemia in the future.
Study context
- Population
- Swedish population-based cohort aged 50–64 years; coronary CT angiography and carotid US
- Participants
- 30,154 participants
- Exposure
- Prediabetes and diabetes vs normoglycaemia
- Prediabetesn = 4,804
- Diabetesn = 2,282
- Outcome
- Prevalence of coronary atherosclerosis (affected segments, stenosis severity, CACS, Segment Involvement Score, any coronary atherosclerosis) and carotid plaque
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
Prediabetes or diabetes had greater coronary plaque burden, more coronary stenosis and higher coronary artery calcium score (CACS) than normoglycaemic participants
all, p < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | Normoglycaemic | Diabetes |
|---|---|---|
| CACS ≥ 100, men | 16.1% | 35.3% |
| CACS ≥ 100, women | 6.1% | 8.9% |
Original publication
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