Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Incident Type 2 Diabetes Risk
Main finding · Incident T2DResult — go to the resultHigher risk 23% CI 1.04–1.45Authors' conclusion
CHIP was associated with higher incidence of T2D. CHIP mutations located on genes implicated in CHD and mortality were also related to T2D, suggesting shared aging-related pathology.
Study context
- Population
- Participants of NHLBI Trans-Omics for Precision Medicine (TOPMed) prospective cohorts without prior T2D, cardiovascular disease or cancer; mean age 63.4 (SD 11.5) years, 76% female
- Participants
- 17,637 participants6 cohorts
- Exposure
- Baseline CHIP vs no CHIP
- CHIPn = 1,055
- Outcome
- Incident T2D
- Follow-up
- Mean 9.8 years
Methodological detailssix cohorts, fixed-effects meta-analysis, multivariable-adjusted
- Six cohorts
- Fixed-effects meta-analysis
- Multivariable-adjusted
Main finding
As reported in the abstract
Higher risk
23%
CI 1.04–1.45
- T2D diagnosed
- 2,467
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Incident T2D by CHIP gene mutationTET2vs No CHIP | 1.48 (1.05–2.08) | |
| Incident T2D by CHIP gene mutationASXL1vs No CHIP | 1.76 (1.03–2.99) | |
| Incident T2D by CHIP gene mutationDNMT3Avs No CHIP | 1.15 (0.93–1.43) | |
| 0.20.5125Hazard ratio (log scale) |
Incident T2D by CHIP gene mutation
- Statistical power was limited for JAK2 and TP53 analyses
CHIP prevalence at baseline
- CHIP prevalence
- 6.0%
Original publication
Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Incident Type 2 Diabetes Risk. Diabetes Care. Published 27 September 2023. doi:10.
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