Clonal hematopoiesis of indeterminate potential, health indicators, and risk of cardiovascular diseases among patients with diabetes: a prospective cohort study
Authors' conclusion
CHIP is independently associated with an increased risk of CVD in patients with diabetes, regardless of health indicator levels. Diabetic patients with CHIP but ideal health indicators still exhibited higher CVD risk compared with diabetic patients without CHIP.
Study context
- Population
- Adults with diabetes, free of cardiovascular diseases (CVD), with available whole-exome sequence data, UK Biobank5,366 developed CVD
- Participants
- 22,239 adults
- Exposure
- Clonal hematopoiesis of indeterminate potential (CHIP) vs no CHIP
- Outcome
- Incident CVD
- Follow-up
- Median 13.2 years
Methodological detailsUK Biobank, multivariable-adjusted Cox regression
- UK Biobank
- Multivariable-adjusted Cox regression
Main finding
As reported in the abstract
Each group vs without CHIPHazard ratio (95% CI)
Any CHIP
1.21(1.08–1.36)
Large CHIP
1.25(1.09–1.43)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD subtypes, any CHIPAny CHIPvs Without CHIPCoronary heart disease | 1.18 (1.03–1.36) | |
| CVD subtypes, any CHIPAny CHIPvs Without CHIPHF | 1.73 (1.46–2.06) | |
| CVD subtypes, any CHIPAny CHIPvs Without CHIPStroke; not significant | 1.14 (0.89–1.48) | |
| 0.512Hazard ratio (log scale) |
Gene-specific CHIP and CVD
- SF3B1, HR
- 2.50, 1.25-5.01 (95% CI)
- TET2, HR
- 1.36, 1.07-1.77 (95% CI)
- Greatest associations
Any CHIP with ideal health indicators vs no CHIP, CVD
- Ideal BMI, HR
- 1.18, 0.82-1.68 (CI)
- Ideal HbA1c, HR
- 1.12, 0.96-1.30 (CI)
- Ideal BP, HR
- 1.24, 1.03-1.49 (CI)
- Ideal LDL-C, HR
- 1.29, 1.09-1.53 (CI)
- No significant interaction between the four health indicators and CHIP
- Similar results with large CHIP
Original publication
Clonal hematopoiesis of indeterminate potential, health indicators, and risk of cardiovascular diseases among patients with diabetes: a prospective cohort study. Cardiovasc Diabetol. Published 13 February 2025. doi:10.
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