Lower Glycosylated Hemoglobin Is Associated With Lower In-Hospital Mortality in Patients With COVID-19: A Systematic Review of the Literature and Meta-Analysis
Pooled result · In-hospital mortality (HbA1c dichotomous)Result — go to the resultOdds ratio 0.53 95% CI 0.37–0.76Authors' conclusion
A better glycemic control prior to hospitalization, as reflected by lower HbA1c, is associated with lower in-hospital mortality in patients with COVID-19.
Study context
- Population
- Hospitalised patients with COVID-19; studies from Pubmed, Embase and Web of Science
- Participants
- 11,220 patients22 studies
- Comparison
- Lower vs higher HbA1c
- Outcome
- In-hospital mortality
Methodological detailsrandom-effects meta-analysis, Heterogeneity assessed with I2; publication bias with funnel plots
- Random-effects meta-analysis
- Heterogeneity assessed with I2; publication bias with funnel plots
Pooled result
In-hospital mortality (HbA1c dichotomous)
Odds ratio
0.53
95% CI 0.37–0.76
Lower HbA1cvs Higher HbA1c
OR 0.53 (95% CI 0.37–0.76)
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| In-hospital mortality, patients with DM only | 0.67 (0.47–0.96) | |
| In-hospital mortality, subgroup HbA1c cutoff 6.5% | 0.34 (0.15–0.77) | |
| In-hospital mortality, subgroup HbA1c cutoff 7% | 0.54 (0.32–0.90) | |
| 0.10.31310Odds ratio (log scale) |
In-hospital mortality, subgroups HbA1c cutoff 7.5% and ≥8%
- Association not statistically significant with cutoffs 7.5% and ≥8%
In-hospital mortality, HbA1c as continuous variable
- No statistically significant association, in univariate or multivariate analyses
Original publication
Lower Glycosylated Hemoglobin Is Associated With Lower In-Hospital Mortality in Patients With COVID-19: A Systematic Review of the Literature and Meta-Analysis. Endocr Pract. Published 27 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →