Arterial stiffness and subclinical atherosclerosis in the coronary arteries at different stages of dysglycaemia
Authors' conclusion
Our results show that increased arterial stiffness and subclinical coronary artery atherosclerosis are present in the early stages of dysglycaemia, but the overlap between markers of major subclinical vascular damage was small in all glycaemic categories. This could be explained by different pathways in the pathogenesis of arterial stiffness or atherosclerosis in the coronary arteries.
Study context
- Population
- Participants aged 50–64 years from SCAPIS; 1964 (21%) with dysglycaemia
- Participants
- 9,379 participants
- Exposure
- Normoglycaemia vs pre-diabetes vs diabetes
- Diabetesn = 742
- Outcome
- Arterial stiffness (PWV ≥10 m/s) and coronary artery calcification (CACS ≥100)
Main finding
As reported in the abstract
| Group | Value | Coronary artery calcium score (CACS) ≥100 |
|---|---|---|
| Normoglycaemia | 11% | 801 (11%) |
| Pre-diabetes | 16% | 190 (16%) |
| Diabetes | 27% | 191 (28%) |
Value
Normoglycaemia11%
Pre-diabetes16%
Diabetes27%
Coronary artery calcium score (CACS) ≥100
Normoglycaemia801 (11%)
Pre-diabetes190 (16%)
Diabetes191 (28%)
- Between Normoglycaemia and Diabetes: P < 0.001 — across glycaemic categories, for both pulse wave velocity (PWV) ≥10 m/s and CACS ≥100
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Fully adjusted associations with glycaemic statusPre-diabetesvs NormoglycaemiaCACS ≥100; no difference | 1.2 (0.98–1.4) | |
| 0.512Odds ratio (log scale) |
| Outcome | Normoglycaemia | Pre-diabetes | Diabetes |
|---|---|---|---|
| Overlap of PWV ≥10 m/s and CACS ≥100 | 2.5% | 3.6% | 10 |
Fully adjusted associations with glycaemic status
- Association between glycaemic status and increased PWV in fully adjusted models
- No association between glycaemic status and CACS ≥100
HbA1c and PWV, total population
- Association between HbA1c and PWV after adjustment
- P < 0.001
Original publication
Arterial stiffness and subclinical atherosclerosis in the coronary arteries at different stages of dysglycaemia. Diabet Med. Published 8 April 2023. doi:10.
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