Impact of diabetes and glycemic status on ventricular–arterial coupling in the general population
Authors' conclusion
This study demonstrates a significant association between DM and impaired VAC, as reflected by elevated PWV/GLS, while no such link was observed in prediabetes. The transition from prediabetes to DM appears critical for VAC deterioration. Additionally, higher HbA1c and fP-glucose levels, even in non-diabetic individuals, were associated with worsened VAC, highlighting the impact of glycemic control on vascular function.
Study context
- Population
- General population participants of the Swedish CArdioPulmonary BioImage Study (SCAPIS) with echocardiography and Pulse wave velocity (PWV) data; mean age 57 years, 48% maleSCAPIS
- Participants
- 2,884 participants
- Exposure
- Glycemic status vs normoglycemia; HbA1c and FPG as continuous exposures
- Diabetes mellitus (DM)n = 162
- Prediabetesn = 334
- Outcome
- Ventricular-arterial coupling (VAC) quantified as the ratio of PWV to GLS (PWV/GLS)
Methodological detailspopulation-based, linear regression, fully adjusted
- Population-based
- Linear regression, fully adjusted
Main finding
As reported in the abstract
Prevalent DM associated with increased PWV/Global longitudinal strain (GLS): Beta
0.28
p < 0.001
DM and prediabetes combined associated with increased PWV/GLS: Beta
0.14
p < 0.001
Increasing HbA1c associated with higher PWV/GLS: Beta
0.01
p < 0.001
Increasing FPG associated with higher PWV/GLS: Beta
0.07
p < 0.001
Observational data: associations, not effects.
Further findings
PWV/GLS in participants without prevalent DM
- Higher HbA1c linked to increased PWV/GLS in age- and sex-adjusted model; attenuated after further adjustment
- FPG remained significantly associated with elevated PWV/GLS across all adjusted models
Original publication
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