Association of C-reactive protein-triglycerides-glucose index-waist to height ratio and cardiometabolic multimorbidity in middle-aged and older adults: a nationwide cohort study
Main finding · Incident CMM by baseline CTI-WHtRResult — go to the resultHazard ratio 2.85 95% CI 2.26–3.58Authors' conclusion
Both baseline and cumulative CTI-WHtR are strong, independent, and non-linear predictors of new-onset CMM.
Study context
- Population
- Middle-aged and older adults in the China Health and Retirement Longitudinal Study (CHARLS), free of cardiometabolic multimorbidity (CMM) at baseline (2011)Cohort 1
- Participants
- 8,875 participants
- Exposure
- Highest vs lowest quartile of baseline CTI-WHtR
- Outcome
- New-onset cardiometabolic multimorbidity (≥ 2 of diabetes, heart disease, or stroke)
Methodological detailsnationwide, CHARLS data
- Nationwide
- CHARLS data
Main finding
Incident CMM by baseline CTI-WHtR
Hazard ratio
2.85
95% CI 2.26–3.58
P < 0.001
Q4vs Q1
HR 2.85 (95% CI 2.26–3.58); P < 0.001
As reported in the abstract
- Incident CMM cases, Cohort 1
- 873
Observational data: associations, not effects.
Further findings
Incident CMM by cumulative CTI-WHtR (Cohort 2, n = 5,807; exposure up to 2015)
| HR (95% CI) | ||
|---|---|---|
| Q4 | 2.76 (2.04–3.75) | |
| 0.20.5125Hazard ratio (log scale) |
- Incident CMM by cumulative CTI-WHtR (Cohort 2, n = 5,807; exposure up to 2015) — Incident CMM cases, Cohort 2
- 490
Shape of association (RCS)
- Non-linear association with a significant inflection point
Predictive performance
- Baseline and cumulative CTI-WHtR predicted CMM better than CTI or WHtR alone
Sensitivity analyses
- Results robust across multiple sensitivity analyses
Original publication
Association of C-reactive protein-triglycerides-glucose index-waist to height ratio and cardiometabolic multimorbidity in middle-aged and older adults: a nationwide cohort study. Cardiovasc Diabetol. Published 1 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →