Type 2 & other diabetes

Produce Prescription Subsidy for Patients With Diabetes: A Pragmatic Randomized Clinical Trial

JAMA Intern MedPublished Randomised controlled trial

Primary result · HbA1cResult — go to the resultAdjusted between-arm difference 0.20 percentage points 95% CI 0.05%–0.35%

Authors' conclusion

This randomized clinical trial found that the PRx program did not improve cardiometabolic health or health care utilization at 12 months. A produce prescription subsidy alone did not improve outcomes among patients with diabetes at risk for food insecurity.

Study context

Population
Patients with diabetes at risk for food insecurity, integrated academic health system in the southeastern US; mean (SD) age 56 (14) years, 71% female, mean baseline hemoglobin A1c (HbA1c) 7.48%randomized
Participants
2,155 patients
Comparison
Produce prescription vs usual care
  • PRxn = 1,450
  • Usual caren = 705reference
Primary endpoint
HbA1c levels and ED visits
Follow-up
12 months following randomization
Methodological details2-arm, pragmatic, stratified by mean HbA1c during past year (≥8% vs <8%), Recruited June–August 2023; followed up for 12 months
  • 2-arm
  • Pragmatic
  • Stratified by mean HbA1c during past year (≥8% vs <8%)
  • Recruited June–August 2023; followed up for 12 months

Primary result

HbA1c · up to 12 months

Adjusted between-arm difference

0.20 percentage points

95% CI 0.05%–0.35%

PRxvs Usual care
adjusted between-arm difference 0.20 percentage points (95% CI 0.05%–0.35%)

As reported in the abstract

Secondary outcomes

Blood pressure, BMI and inpatient visits · up to 12 months

No significant between-group differences in blood pressure, BMI and inpatient visits

Subgroup with elevated HbA1c (≥8%) · up to 12 months

Results similar in subgroup with HbA1c ≥8%
n = 651

Benefit use

Participants using 80% or more per month
433 (30%)

Original publication

Produce Prescription Subsidy for Patients With Diabetes: A Pragmatic Randomized Clinical Trial. JAMA Intern Med. Published 1 April 2026. doi:10.1001/jamainternmed.2025.8008

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