Produce Prescription Subsidy for Patients With Diabetes: A Pragmatic Randomized Clinical Trial
Primary result · HbA1cResult — go to the resultAdjusted between-arm difference 0.20 percentage points 95% CI 0.05%–0.35%Authors' conclusion
This randomized clinical trial found that the PRx program did not improve cardiometabolic health or health care utilization at 12 months. A produce prescription subsidy alone did not improve outcomes among patients with diabetes at risk for food insecurity.
Study context
- Population
- Patients with diabetes at risk for food insecurity, integrated academic health system in the southeastern US; mean (SD) age 56 (14) years, 71% female, mean baseline hemoglobin A1c (HbA1c) 7.48%randomized
- Participants
- 2,155 patients
- Comparison
- Produce prescription vs usual care
- PRxn = 1,450
- Usual caren = 705reference
- Primary endpoint
- HbA1c levels and ED visits
- Follow-up
- 12 months following randomization
Methodological details2-arm, pragmatic, stratified by mean HbA1c during past year (≥8% vs <8%), Recruited June–August 2023; followed up for 12 months
- 2-arm
- Pragmatic
- Stratified by mean HbA1c during past year (≥8% vs <8%)
- Recruited June–August 2023; followed up for 12 months
Primary result
HbA1c · up to 12 months
Adjusted between-arm difference
0.20 percentage points
95% CI 0.05%–0.35%
PRxvs Usual care
adjusted between-arm difference 0.20 percentage points (95% CI 0.05%–0.35%)
As reported in the abstract
Secondary outcomes
Blood pressure, BMI and inpatient visits · up to 12 months
- No significant between-group differences in blood pressure, BMI and inpatient visits
Subgroup with elevated HbA1c (≥8%) · up to 12 months
- Results similar in subgroup with HbA1c ≥8%
- n = 651
Benefit use
- Participants using 80% or more per month
- 433 (30%)
Original publication
Produce Prescription Subsidy for Patients With Diabetes: A Pragmatic Randomized Clinical Trial. JAMA Intern Med. Published 1 April 2026. doi:10. 1001/ jamainternmed. 2025. 8008
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