Association between atherogenic index of plasma and all-cause mortality and specific-mortality: a nationwide population‑based cohort study
Authors' conclusion
In this study, there is a no significant association between high AIP levels and a high risk of all-cause and cardiovascular mortality. Besides, a higher AIP was significantly associated with an increased risk of diabetes mortality, which only found in women older than 65 years. AIP was associated with all-cause mortality in a U-shape. This association could be explained by the finding that higher AIP predicted a higher risk of death from diabetes, and that lower AIP predicted a higher risk of death from non-diabetes causes.
Study context
- Population
- American adults; Atherogenic index of plasma (AIP) defined as log10 (TG/HDL-C)
- Participants
- 14,063 adults
- Exposure
- Highest vs lowest quantile of AIP
- Outcome
- All-cause mortality and specific-mortality (diabetes, CVD, cancer)
- Follow-up
- 10 years
Methodological detailsnationwide, survey-weighted Cox regression, weighted restricted cubic spline
- Nationwide
- Survey-weighted Cox regression
- Weighted restricted cubic spline
Main finding
As reported in the abstract
- All-cause mortality cases
- 2,077
- Diabetes mortality cases
- 262
- Cardiovascular disease (CVD) mortality cases
- 854
- Cancer mortality cases
- 476
- AIP not significantly associated with all-cause, CVD and cancer mortality
- p > 0.05
- U-shaped non-linear association between AIP and all-cause mortality
- p for non-linear = 0.0011
- Linear relationship of AIP with diabetes and non-diabetes mortality
- p for linear < 0.0001
Observational data: associations, not effects.
Further findings
Diabetes mortality, highest vs lowest AIP quantile, in females
- AIP significantly associated with increased risk of diabetes mortality in females
- P for trend = 0.001
Diabetes mortality, highest vs lowest AIP quantile, in participants older than 65 years
- AIP significantly associated with increased risk of diabetes mortality in participants >65 years
- P for trend = 0.002
Original publication
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