Postprandial fatty acid-binding protein 4 is associated with muscle insulin resistance
Authors' conclusion
These results suggested that the postprandial FABP4 level is associated with insulin resistance, and FABP4 may suppress insulin signals.
Study context
- Population
- Participants with and without T2D; mouse C2C12 muscle cells
- Participants
- 22 vs 26
- Comparison
- T2D vs no diabetes
- T2Dn = 22
- Without diabetesn = 26reference
- Outcome
- Postprandial serum FABP4
Methodological detailsmeal tolerance test, hyperinsulinaemic-euglycaemic clamp, in vitro C2C12 muscle cell experiments
- Meal tolerance test
- Hyperinsulinaemic-euglycaemic clamp
- In vitro C2C12 muscle cell experiments
Main finding
As reported in the abstract
Without diabetes: postprandial FABP4 vs muscle insulin resistance M/I value (clamp), r
r=−0.42
p<0.05
T2D: postprandial increase in FABP4 vs M/I value, r
r=−0.44
p<0.05
T2D: postprandial increase in FABP4 vs fasting–postprandial glucagon difference, r
r=0.36
p<0.05
Original publication
Postprandial fatty acid-binding protein 4 is associated with muscle insulin resistance. Diabetologia. Published 26 July 2024. doi:10.
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