All-cause Mortality and Incidence of Cardiovascular Diseases in Lean Patients With Newly Diagnosed Type 2 Diabetes
Main finding · All-cause mortalityResult — go to the resultHazard ratio 2.106 95% CI 1.974–2.248Authors' conclusion
Our findings underscore the critical role of maintaining an appropriate weight status to reduce all-cause mortality and incidence of cardiovascular diseases among lean patients with newly diagnosed type 2 diabetes.
Study context
- Population
- Patients with newly diagnosed T2D who underwent health screening 2010–2014 in Korea, followed up until 2019
- Participants
- 419,509 patients
- Exposure
- Lean body mass index (BMI) vs normal BMI in newly diagnosed T2D
- Outcome
- All-cause mortality and incidence of CVD
Methodological detailsmultivariate Cox proportional hazards model
- Multivariate Cox proportional hazards model
Main finding
All-cause mortality
Hazard ratio
2.106
95% CI 1.974–2.248
Leanvs Normal BMI
HR 2.106 (95% CI 1.974–2.248)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD | 1.132 (1.078–1.189) | |
| Coronary heart disease | 1.219 (1.124–1.323) | |
| HF | 1.405 (1.279–1.543) | |
| Stroke | 1.155 (1.024–1.302) | |
| Ischemic stroke | 1.205 (1.045–1.388) | |
| 0.512Hazard ratio (log scale) |
All-cause mortality by BMI change over time
- Highest all-cause mortality in those who remained lean during follow-up
Original publication
All-cause Mortality and Incidence of Cardiovascular Diseases in Lean Patients With Newly Diagnosed Type 2 Diabetes. J Clin Endocrinol Metab. Published 26 July 2024. doi:10.
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