In vivo molecular imaging of cardiac angiogenesis in persons with and without type 2 diabetes: A cross‐sectional 68 Ga‐RGD‐positron emission tomography (PET) study
Authors' conclusion
Cardiac angiogenesis, evaluated with 68 Ga-RGD PET, was similar in type 2 diabetes and CONs. Cardiac angiogenesis was not associated with kidney function or other risk markers in pooled analyses or in analyses restricted to type 2 diabetes.
Study context
- Population
- Persons with T2D (mean age 61 ± 9 years, 30% women, median diabetes duration 11 years, 15% history of CVD) and non-diabetic controls of comparable age and sex
- Participants
- 20 vs 10
- Exposure
- T2D vs non-diabetic controls
- T2Dn = 20
- Controls (CONs)n = 10reference
- Outcome
- Difference in cardiac angiogenesis (cardiac 68Ga-RGD mean target-to-background ratio [TBRmean]) between T2D and CONs
Methodological details68Ga-RGD PET imaging
- 68Ga-RGD PET imaging
Main finding
As reported in the abstract
Cardiac 68Ga-RGD TBRmean
T2D
0.89
mean · SD 0.09
CONs
0.89
mean · SD 0.10
P = 0.92
Observational data: associations, not effects.
Secondary outcomes
| Outcome | T2D | CONs | P value |
|---|---|---|---|
| Myocardial flow reserveLower in T2D | 2.7 ± 0.6 | 3.4 ± 1.2 | P = 0.03 |
| Coronary artery calcium scoreHigher in T2D | 562 (range in brackets 142–905) | 1 (range in brackets 0–150) | P = 0.04 |
Associations of cardiac 68Ga-RGD TBRmean with risk factors
- Not associated with eGFR, urine albumin creatinine ratio, CVD, coronary artery calcium score or baroreflex sensitivity, in pooled analyses or in T2D
Original publication
In vivo molecular imaging of cardiac angiogenesis in persons with and without type 2 diabetes: A cross‐sectional 68 Ga‐RGD‐PET study. Diabet Med. Published 6 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →